Why genome editing

With the discovery of CRISPR, the possibility of precise genome editing has allowed the world to rethink its approach to serious challenges in agriculture, food and pharma. In agriculture, we now have the ability to further improve crops that have already undergone extensive breeding, with great speed and preserving the improvements realized so far. HRB applies CRISPR-based genome editing towards genetic crop optimization for improved yields, disease resistance and nutritional value. Ultimately we aim to contribute to solving global challenges associated with increased demand for food and natural ingredients produced in a way that ensures a sustainable future.

Why Hudson River Biotechnology

We employ state-of-the-art science and the latest genetic technologies to optimize plants. HRB can be your co-development partner for all aspects of genome editing projects, as our TiGER platform offers the full spectrum of technologies needed. For partners who already have substantial in-house capabilities, HRB can supplement by providing proprietary solutions to specific parts of the workflow (for example, providing genome-wide data on gene regulatory elements in the genome, enhancing transfection capabilities, developing crop-specific applications). For other partners, we can provide a complete end-to-end solution, from a concept to a modified crop ready for field or greenhouse testing. This includes all technical aspects such as target identification, CRISPR guide design and validation, transfection (entry) and plant regeneration, as well as commercial aspects such as navigating the regulatory environment and intellectual property landscape.

How to work with HRB

We enable companies of all sizes – from seed companies, ingredient producers or buyers to other biotech firms – to create tomorrow’s crops with today’s technologies.

Plant seed and breeding companies

Seed companies with existing genomic capabilities often face specific technological barriers to gene editing such as unique target discovery, transfection efficiency, guide design and difficulties with plant regeneration. HRB has, and is continuously improving, solutions to all of these problems and can act as a technology provider or trait development partner. Either through breeding projects, technological co-development or licensing, HRB brings the solutions you need.

Food and ingredient companies

Gene editing opens up a whole new range of possibilities to food and ingredient companies. HRB has the in-house R&D capabilities to create completely new varieties that will amaze consumers with healthier and more nutritious products. We look forward to partnering with you. Get in touch with us today!

Biotechnology companies

Aspects of HRB’s TiGER workflow are excellently suited for pushing biotechnological solutions forward. Our methods for CRISPR guide design and intracellular delivery are well-suited for different microorganisms and algae, with or without cell walls, and plant-based ingredient-production platforms. Feel invited to reach out if you want to discuss the opportunities on this front.

CRISPR in the EU

For the time being, CRISPR-edited plant crops are considered GMOs and as such essentially barred from entering the market. However, even for EU applications CRISPR has tremendous value as an accelerator of conventional breeding technologies. For example, we can identify genetic targets and confirm these via CRISPR, after which we genetically screen through a large population of randomly mutagenized plants to identify similar mutants. This results in new varieties that are fully compliant with EU regulations. For more details, including how CRISPR can be applied in your geographical area(s) of interest, please contact us.

Our facilities

HRB’s laboratory facilities are located in the Wageningen BioPartner center and are fully equipped for our activities related to DNA, RNA, proteins, microorganisms and plants. In addition HRB maintains an official collaboration with nearby Wageningen University as well as several other academic research institutions, providing us access to their extensive research infrastructure and the latest academic insights.